澳大利亚澳新军团研究所 骨分子生物学实验室主任、悉尼大学教授

时间： 　　2016年5月20日 上午10:30—12:00

地点： 　　深圳大学南校区医学院208会议室

主持人：   周光前 教授

 

周虹教授简介

Professor Hong Zhou is a Senior Principal Research Fellow at the University of Sydney and Head of the Molecular Bone Biology Laboratory at the ANZAC Research Institute, Sydney. She has extensive experience in the cell and molecular biology of musculoskeletal tissues, glucocorticoid signalling and animal models of bone and joint pathology. In past 5 years, her research was supported by 7 NHMRC project grants. Over the course of her career, she has published 94 scientific reports (29 in the past 5 years), many of which appeared in top-ranking journals such as J Clin Invest, J Exp Med, PNAS, Development, Arthritis Rheum, JBMR, Diabetes, Cancer Res, JBC and Bone. 

 

 

 

讲座摘要

 

Glucocorticoids are pleiotropic hormones with regulatory roles in fuel metabolism, immune defence, bone and connective tissue homeostasis as well as growth and development. Clinically, glucocorticoids are widely used for their unsurpassed anti-inflammatory and immunomodulatory effects. However, the therapeutic use of glucocorticoids is almost always limited by significant adverse effects such as osteoporosis, diabetes and obesity. Recent insights into the mechanisms of action of both endogenous and exogenous glucocorticoids in bone cells have unlocked new potential approaches for the prevention and treatment of glucocorticoid-induced osteoporosis. Furthermore, studies in rodents indicate that the osteoblast-derived peptide, osteocalcin, plays a central role in the pathogenesis of glucocorticoid-induced diabetes and obesity. More recently, glucocorticoid signalling in bone cells has been found to be central in the regulation of age-related changes andhigh-fat diet induced changes in body composition and glucose metabolism.